Polishing in Downstream Processing

Flexibility is a key requirement for biopolishing finish workflows. CPC aseptic connectors provide flexibility to easily combine multiple components including process containers, tubing manifolds, single-use and metal transfer lines, bioreactors and other bioprocess equipment. When changeovers need to occur, genderless CPC aseptic connectors make it easy to connect and disconnect components and processes. Multiple termination options meet today’s mounting and flow requirements.

CPC’s comprehensive portfolio of aseptic connectors with multiple sizes, configurations, termination options and materials for use with a wide variety of polishing techniques. Innovative connection methods help eliminate contamination risk and ensure connection assurance. CPC’s biopharma design and application engineers develop innovative, high-quality products that make sterile media transfer during the biopolish process safe and easy.

CPC sterile connectors are engineered for upstream and downstream processing including polishing. By helping maintain aseptic transfer of media and impurities removal, CPC sterile connectors facilitate getting the best biologic product yields at a cost-effective price. All CPC aseptic connection solutions are rigorously tested ─ including materials testing, product testing and torture testing to failure ─ to meet product specifications. As a matter of fact, CPC offers reliable, reproducible performance and provides validation and extractable reports that support the performance attributes.

CPC aseptic connectors deliver optimized flowrates with excellent flow to size ratio for superior performance to manage the media and impurities fluid transfer required during polishing. CPC purpose-built connectors are designed to be compatible with the wide variety of polishing platforms and processes. We provide a unique combination of industry expertise with the broadest portfolio of products including sterile connects, sterile disconnects, SIP connections and quick connects.

Increased cell densities and complex polishing fluids mean manufacturers must design their facilities to manage shorter production runs with multiple changeovers. Single-use bags and transfer lines use CPC MPC or MPX Connections and SaniQuik^™ Adaptors for quick changeovers. Robust and easy-to-use, single-use, aseptic connectors from CPC maintain flow path sterility and integrity while enabling biopharmaceutical manufacturers to use the appropriate biopolishing processes and platforms to improve biologic product yields and reduce costs.

CPC has a proven track record of providing products consistently under their stated specifications and quality requirements through having a strong supply assurance program. The program includes control of the manufacturing process from raw materials to final product manufacturing. Investments in extra capacity and redundant manufacturing ensure capacity when it’s needed. Biopharma customers have confidence in CPC’s ability to fulfill demand acquired by a track record of accurate lead times, identifying and communicating potential delays and, most importantly, by sound supply chain management.