Single-Use Connectors for Upstream Processing in Fermentation

One of the initial phases of the bioprocessing upstream process is fermentation. Fermentation is defined as a chemical change brought about by using microorganisms for production of pharmaceuticals and other biotechnology products. The process is usually conducted in bioreactors or fermenters depending on the media being cultivated. These bioreactor tanks allow for the microbial (or mammalian) growth and product synthesis under strictly monitored and controlled conditions.

Fermentation Lays the Foundation for Final Product Production

Bioprocessing companies, as well as those companies focused on cell and gene therapeutic products, understand that the fermentation application must provide an optimal microbial synthesis environment. Additionally, the fermentation process must help ensure an economically feasible production yield in a form that allows for cost-efficient, large-scale production.

Modern bioprocessing facilities have capacities that can range from 1,000 to 25,000 liters. Scaling up the biologic material from a few million cells in several milliliters of culture to these production volumes is a challenge that requires aseptic media transfer at each point along the seed train.

Single-Use Technology Helps Increase Fermentation Efficiency

Advances in single-use technology (SUT) provide bioprocessing engineers the option to replace their storage vessels and fixed piping networks with single-use systems and transfer lines. With the increased adoption of single-use technology, bioprocessing manufacturers are able to design flexible seed train systems consisting of various volume single-use bioreactors (SUBs) or implement a hybrid design using SUBs and traditional stainless reactors for exceptionally large volumes. The use of CPC sterile connectors, or sanitary fittings with Steam in Place (SIP) connections, allows for easy and safe media transfer when joining various components.

Collaborate with CPC to Help Optimize Your Fermentation Workflow

CPC’s team of bioprocessing engineers collaborates with you to accelerate your bioprocessing applications from R&D to scale-up for commercial readiness. CPC has over 20 years of experience improving the fermentation process through safe and efficient media transfer using single-use connectors and connection technology. With a market-neutral position and global distribution, CPC products are available everywhere, all the time.

By partnering with CPC, you can be assured of an optimal workflow design for your upstream and downstream applications.

Single Use Technology Advantages

Eliminates the need for Clean in Place (CIP) validation for many components
Reduces maintenance and capital expense
Eliminates expensive vessels, valve and sanitary piping assemblies
Increases process flexibility
Reduces changeover turnaround time

CPC Single-Use Sterile Connectors Designed for Fermentation Process

Biopharmaceutical manufacturers deploy a wide range of single-use subsystems including bags, tubing manifolds and filter assemblies to create their desired fermentation and production processes. CPC offers the widest range of single-use connection solutions to reliably bring these technologies together while maintaining the sterility and integrity of the overall system.

Versatility and Flexibility

CPC sterile connectors provide flexibility for biopharmaceutical manufacturers to easily combine multiple components, single-use or hybrid systems including process containers, tubing manifolds, transfer lines, bioreactors and other bioprocess equipment. When changeovers need to occur, CPC genderless connectors make it easy to pull stock and connect components and processes, resulting in increased flexibility. Multiple termination options meet today’s mounting and flow requirements.

Innovative Design

Our team of bioprocessing design and application engineers focus on developing innovative, high-quality products that make sterile media transfer safe and easy. Because fermentation component configurations within transfer lines vary as much as the options for tubing, connectors and filters, CPC sterile connectors come in an expanding variety of sizes, configurations, termination options and materials. The innovative, Flip-Click-Pull connection process ensures ease of use and connection assurance.Trusted Reliability

Trusted Reliability

CPC sterile connectors are purpose-built for bioprocessing applications from upstream fermentation to downstream freeze-thaw―and everything in-between. By helping maintain aseptic transfer of media, CPC sterile connectors facilitate getting the best yields at a cost-efficient price. All CPC bioprocessing connection solutions are rigorously tested ─ including materials testing, product testing and torture testing to failure ─ to meet product specifications. As a matter of fact, CPC offers reliable, reproducible performance and provides validation and extractable reports that support the performance attributes.

Overall Robustness

Built to manage the media transfer requirements of bioreactors and fermentor machines, CPC sterile connectors deliver optimized flowrates with excellent flow to size ratio for superior performance. CPC sterile connectors are precision engineered to be compatible with a wide variety of fermentation components, chemicals, media and systems. We provide a unique combination of industry expertise with the broadest portfolio of products including sterile connect, sterile disconnect, SIP connections and quick connects.

Sterility Assurance

Increased volume and product diversity is driving manufacturers to design their facilities for shorter production runs with multiple changeovers. Single-use bags and transfer lines use CPC MPC or MPX Connections and SaniQuik^™ Adaptors for quick changeovers. Employing Steam-Thru^® Connections allows operators to make a sterile connection between pre-sterilized single-use systems and fermentation equipment for aseptic media transfer. Robust and easy-to-use single-use connectors from CPC maintain flow path sterility and integrity while enabling biopharmaceutical manufacturers to improve production yields, decrease time-to-market and reduce costs.

Assurance of Supply

CPC has a proven track record of providing products consistently under their original specifications and quality requirements through having a strong supply assurance plan. The plan includes control of the manufacturing process from raw materials to final product manufacturing. Biopharma customers have confidence in CPC to deliver critical products acquired by a track record of accurate lead times, identifying and communicating potential delays and, most importantly, by sound supply chain management.

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Upstream Processing: Fermentation